Laboratorio de Patogenia Bacteriana (PatoBac)


Directores:

Dra. Buzzola, Fernanda

Dr. Sordelli, Daniel

Integrantes:

Dr. Suligoy Lozano, Mauricio

Dra. Cáceres, María Emilia

Lic. Diaz, Rocío

Tec. Medina, Lorena


Estudiamos aspectos relacionados con la patogenia y el control de las infecciones bacterianas en el hombre y en bovinos. Nos interesa entender los mecanismos adaptativos de Staphylococcus aureus a diferentes nichos evaluando los factores involucrados y la plasticidad genómica. Analizamos los efectos que ejercen ciertos agentes farmacológicos o sus derivados sobre la biopelícula bacteriana. Usamos una variedad de técnicas de la microbiología clásica, molecular y celular, herramientas bioinformáticas y modelos murinos de infección.


Publicaciones destacadas:
  • Marbach H, Mayer K, Vogl C, Lee JYH, Monk IR, Sordelli DO, Buzzola FR, Ehling-Schulz M and Grunert T. Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic activity and biofilm formation. Scientific Reports (2019) 9:13479. DOI:10.1038/s41598-019-49981-6 1.
  • Grunert T, Stessl B, Wolf F, Sordelli DO, Buzzola FR and Ehling-Schulz M. Distinct phenotypic traits of Staphylococcus aureus are associated with persistent, contagious bovine intramammary infections. Scientific Reports (2018) 8:15968. DOI:10.1038/s41598-018-34371-1.
  • Suligoy CM, Lattar SM, Noto Llana M, Gonzáles C, Alvarez LP, Robinson DA, Gómez MI, Buzzola FR and Sordelli DO. Mutation of Agr is associated with the adaptation of Staphylococcus aureus to the host during chronic osteomyelitis. Front. Cell. Infect. Microbiol.(2018) 8:18. DOI: 10.3389/fcimb.2018.00018.
  • Dotto C, Lombarte Serrat A, Cattelan N, Barbagelata MS, Yantorno O, Sordelli DO, Ehling-Schulz M, Grunert T and Buzzola FR. The active component of aspirin, salicylic acid, promotes Staphylococcus aureus biofilm formation in a PIA-dependent manner. Frontiers Microbiol (2017) 8:4. DOI: 10.3389/fmicb.2017.00004.
  • Gándara L, Mamone L, Cervini Bohm G, Buzzola FR and Casas A. Enhancement of photodynamic inactivation of Staphylococcus aureus biofilms by disruptive strategies. Lasers Med Sci (2017). DOI:10.1007/s10103-017-2253-3.
  • Grunert T, Wenning M, Barbagelata MS, Fricker M, Sordelli DO, Buzzola FR and Ehling-Schulz M. Rapid and reliable identification of Staphylococcus aureus capsular serotypes by means of artificial neural network-assisted Fourier-transform infrared spectroscopy. J. Clin. Microbiol. (2013), 51:2261-2266.
  • Barbagelata MS, Alvarez LP, Gordiola M, Tuchscherr LPN, von Eiff C, Becker K, Sordelli DO and Buzzola FR. Auxotrophic mutant of Staphylococcus aureus interferes with nasal colonization by the wild type. Microbes Infect. (2011), 13:1081-1090.
  • Alvarez LP, Barbagelata MS, Cheung AL, Sordelli DO and Buzzola FR. Salicylic acid enhances Staphylococcus aureus extracellular adhesin protein (Eap) expression. Microbes Infect. (2011), 13:1073-1080.
  • Tuchscherr LPN, Löffler B, Buzzola FR and Sordelli DO. Styaphylococcus aureus adaptation to the host and persistence: the role of loss of capsular polysaccharide expression. Future Microbiol (2010), 5:1823-1832.
  • Alvarez LP, Barbagelata MS, Gordiola M, Cheung AL, Sordelli DO and Buzzola FR. Salicylic acid diminishes Staphylococcus aureus capsular polysaccharide type 5 expression. Infect Immun. (2010),78:1339-1344.

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