Laboratorio de Microbiología Aplicada

Directora:

Prof. Dra. Cerquetti, Maria Cristina

Integrantes:

Dra. Giacomodonato, Mónica Nancy

Dra. Noto Llana, Mariángeles

Dr. Sarnacki, Sebastián

Dra. Garofalo, Ailin Natalia

Lic. Betancourt Gordillo, Diana Marcela

Lic. Abou Assali, Lubna

Gerez, Soledad

Estudio del efecto de enfermedades de transmisión alimentaria (ETA) por Salmonella enterica durante la gestación, el puerperio y la lactancia. Caracterización de Biofilms de Salmonella enterica. Participación de la enzima ADN adenina metiltransferasa en la expresión de genes de patogenicidad de Salmonella enterica.

Publicaciones destacadas:

- Betancourt DM, Llana MN, Sarnacki SH, Cerquetti MC, Monzalve LS, Pustovrh MC, Giacomodonato MN. Salmonella Enteritidis foodborne infection induces altered placental morphometrics in the murine model. Placenta. 2021 Apr 16;109:11-18. doi: 10.1016/j.placenta.2021.04.004.

- Noto Llana M, Sarnacki SH, Morales AL, Aya Castañeda MDR, Giacomodonato MN, Blanco G, Cerquetti MC. Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells. Front Cell Infect Microbiol. 2017 Sep 8;7:398. doi: 10.3389/fcimb.2017.00398.

- Aya Castañeda Mdel R, Sarnacki SH, Noto Llana M, López Guerra AG, Giacomodonato MN, Cerquetti MC. Dam methylation is required for efficient biofilm production in Salmonella enterica serovar Enteritidis. Int J Food Microbiol. 2015 Jan 16;193:15-22. doi: 10.1016/j.ijfoodmicro.2014.10.003.

- Noto Llana M, Sarnacki SH, Aya Castañeda Mdel R, Pustovrh MC, Gartner AS, Buzzola FR, Cerquetti MC, Giacomodonato MN. Salmonella enterica serovar Enteritidis enterocolitis during late stages of gestation induces an adverse pregnancy outcome in the murine model. PLoS One. 2014 Nov 3;9(11):e111282. doi: 10.1371/journal.pone.0111282.

- Giacomodonato MN, Llana MN, Castañeda Mdel R, Buzzola F, García MD, Calderón MG, Sarnacki SH, Cerquetti MC. Dam methylation regulates the expression of SPI-5-encoded sopB gene in Salmonella enterica serovar Typhimurium. Microbes Infect. 2014 Aug;16(8):615-22. doi: 10.1016/j.micinf.2014.03.009.

- Giacomodonato MN, Noto Llana M, Aya Castañeda MDR, Buzzola FR, Sarnacki SH, Cerquetti MC. AvrA effector protein of Salmonella enterica serovar Enteritidis is expressed and translocated in mesenteric lymph nodes at late stages of infection in mice. Microbiology (Reading). 2014 Jun;160(Pt 6):1191-1199. doi: 10.1099/mic.0.077115-0.

- Noto Llana M, Sarnacki SH, Aya Castañeda Mdel R, Bernal MI, Giacomodonato MN, Cerquetti MC. Consumption of Lactobacillus casei fermented milk prevents Salmonella reactive arthritis by modulating IL-23/IL-17 expression. PLoS One. 2013 Dec 10;8(12):e82588. doi: 10.1371/journal.pone.0082588.

- Sarnacki SH, Castañeda Mdel R, Noto Llana M, Giacomodonato MN, Valvano MÁ, Cerquetti MC. Dam methylation participates in the regulation of PmrA/PmrB and RcsC/RcsD/RcsB two component regulatory systems in Salmonella enterica serovar Enteritidis. PLoS One. 2013;8(2):e56474. doi: 10.1371/journal.pone.0056474.

- Noto Llana M, Sarnacki SH, Vázquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC. Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice. Infect Immun. 2012 Jun;80(6):2231-9. doi: 10.1128/IAI.00324-12.

- Giacomodonato MN, Sarnacki SH, Llana MN, Cerquetti MC. SopB effector protein of Salmonella Typhimurium is translocated in mesenteric lymph nodes during murine salmonellosis. FEMS Microbiol Lett. 2011 Apr;317(1):100-6. doi: 10.1111/j.1574-6968.2011.02217.x.

- Giacomodonato MN, Sarnacki SH, Llana MN, Cerquetti MC. Dam and its role in pathogenicity of Salmonella enterica. J Infect Dev Ctries. 2009 Aug 30;3(7):484-90. doi: 10.3855/jidc.465.

- Sarnacki SH, Marolda CL, Noto Llana M, Giacomodonato MN, Valvano MA, Cerquetti MC. Dam methylation controls O-antigen chain length in Salmonella enterica serovar enteritidis by regulating the expression of Wzz protein. J Bacteriol. 2009 Nov;191(21):6694-700. doi: 10.1128/JB.00839-09.

- Giacomodonato MN, Sarnacki SH, Llana MN, García Cattaneo AS, Uzzau S, Rubino S, Cerquetti MC. Impaired synthesis and secretion of SopA in Salmonella typhimurium dam mutants. FEMS Microbiol Lett. 2009 Mar;292(1):71-7. doi: 10.1111/j.1574-6968.2008.01473.x.

- Noto Llana M, Sarnacki SH, Giacomodonato MN, Caccuri RL, Blanco GA, Cerquetti MC. Sublethal infection with Salmonella enteritidis by the natural route induces intestinal and joint inflammation in mice. Microbes Infect. 2009 Jan;11(1):74-82. doi: 10.1016/j.micinf.2008.10.010.

- Giacomodonato MN, Uzzau S, Bacciu D, Caccuri R, Sarnacki SH, Rubino S, Cerquetti MC. SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium are synthesized at late stages of infection in mice. Microbiology (Reading). 2007 Apr;153(Pt 4):1221-1228. doi: 10.1099/mic.0.2006/002758-0.

- Giacomodonato MN, Sarnacki SH, Caccuri RL, Sordelli DO, Cerquetti MC. Host response to a dam mutant of Salmonella enterica serovar enteritidis with a temperature-sensitive phenotype. Infect Immun. 2004 Sep;72(9):5498-501. doi: 10.1128/IAI.72.9.5498-5501.2004.