Laboratorio de Investigaciones de Mecanismos de Resistencia a Ant

Laboratorio de Investigaciones de Mecanismos de Resistencia a Antibióticos

Directoras:

Dra. Centrón, Daniela

Dra. Quiroga, Maria Paula

Integrantes:

Dra. Alvarez, Verónica Elizabeth

Dra. Camicia, Gabriela

Dra. Knecht, Camila Ayelén

Dra. Leguina, Ana Carolina del Valle

Lic. Alonso, Fernando Martín

Lic. Ayala Nuñez, Teolincacihuatl

Lic. Carrera Paez, Laura Camila

Lic. Gambino, Anahí Samanta

Lic. Donis, Nicolas

Lic. Massó, Mariana Guillermina

Lic. Piekar, María

Lic. Vianna, Lorena

Colaboradores:

Barbara Prack Mc Cormick, Universidad Nacional de Lomas de Zamora

Actualmente estamos trabajando en identificar los procesos celulares y moleculares que llevan a la diseminación de los genes de resistencia a antibióticos del ambiente a la clínica en ambas direcciones.

Publicaciones destacadas:

- Louge Uriarte EL, González Pasayo RA, Massó M, Carrera Paez L, Domínguez Moncla M, Donis N, Malena R, Méndez A, Morrell E, Giannitti F, Armendano JI, Faverin C, Centrón D, Parreño V, Odeón AC, Quiroga MP, Moreira AR. Molecular characterization of multidrug-resistant Escherichia coli of the phylogroups A and C in dairy calves with meningitis and septicemia. Microb Pathog. 2022 Feb;163:105378. doi: 10.1016/j.micpath.2021.105378.

- Álvarez VE, Massó MG, D'amico González G, Gambino AS, Knecht CA, Prack Mc Cormick B, Leguina C, Piekar M, Poklepovich T, Campos J, Arduino S, Centrón D, Quiroga MP. Emergence of colistin resistance in Klebsiella pneumoniae ST15 disseminating bla_KPC-2 in a novel genetic platform. J Glob Antimicrob Resist. 2022 Jun;29:537-539. doi: 10.1016/j.jgar.2021.12.001.

- Wehrendt DP, Massó MG, Gonzales Machuca A, Vargas CV, Barrios ME, Campos J, Costamagna D, Bruzzone L, Cisterna DM, Iglesias NG, Mbayed VA, Baumeister E, Centrón D, Quiroga MP, Erijman L. A rapid and simple protocol for concentration of SARS-CoV-2 from sewage. J Virol Methods. 2021 Nov;297:114272. doi: 10.1016/j.jviromet.2021.114272.

- Gambino AS, Déraspe M, Álvarez VE, Quiroga MP, Corbeil J, Roy PH, Centrón D. Serratia marcescens SCH909 as reservoir and source of genetic elements related to wide dissemination of antimicrobial resistance mechanisms. FEMS Microbiol Lett. 2021 Jul 20;368(14):fnab086. doi: 10.1093/femsle/fnab086.

- Alcaraz E, Centrón D, Camicia G, Quiroga MP, Di Conza J, Rossi BP. Corrigendum: Stenotrophomonas maltophilia phenotypic and genotypic features through 4-year cystic fibrosis lung colonization. J Med Microbiol. 2021 Feb;70(2). doi: 10.1099/jmm.0.001312.

- Alcaraz E, Centrón D, Camicia G, Quiroga MP, Di Conza J, Passerini de Rossi B. Stenotrophomonas maltophilia phenotypic and genotypic features through 4-year cystic fibrosis lung colonization. J Med Microbiol. 2021 Jan;70(1). doi: 10.1099/jmm.0.001281.

- Montaña S, Vilacoba E, Fernandez JS, Traglia GM, Sucari A, Pennini M, Iriarte A, Centron D, Melano RG, Ramírez MS. Genomic analysis of two Acinetobacter baumannii strains belonging to two different sequence types (ST172 and ST25). J Glob Antimicrob Resist. 2020 Dec;23:154-161. doi: 10.1016/j.jgar.2020.09.006.

- Álvarez VE, Quiroga MP, Galán AV, Vilacoba E, Quiroga C, Ramírez MS, Centrón D. Crucial Role of the Accessory Genome in the Evolutionary Trajectory of Acinetobacter baumannii Global Clone 1. Front Microbiol. 2020 Mar 18;11:342. doi: 10.3389/fmicb.2020.00342.

- Alonso CA, Cortés-Cortés G, Maamar E, Massó M, Rocha-Gracia RDC, Torres C, Centrón D, Quiroga MP. Corrigendum to "Molecular diversity and conjugal transferability of class 2 integrons among Escherichia coli isolates from food, animal and human sources" [International Journal of Antimicrobial Agents 51 (2018) 905-911]. Int J Antimicrob Agents. 2019 Dec;54(6):834. doi: 10.1016/j.ijantimicag.2019.10.016.

- Parmeciano DI Noto G, Iriarte A, Ramírez MS, Centrón D, Quiroga C. ICE SXT vs. ICESh95: Co-existence of Integrative and Conjugative Elements and Competition for a New Host. Sci Rep. 2019 May 29;9(1):8045. doi: 10.1038/s41598-019-44312-1.

- Traglia G, Chiem K, Quinn B, Fernandez JS, Montaña S, Almuzara M, Mussi MA, Tolmasky ME, Iriarte A, Centrón D, Ramírez MS. Genome sequence analysis of an extensively drug-resistant Acinetobacter baumannii indigo-pigmented strain depicts evidence of increase genome plasticity. Sci Rep. 2018 Nov 16;8(1):16961. doi: 10.1038/s41598-018-35377-5.

- Álvarez VE, Campos J, Galiana A, Borthagaray G, Centrón D, Márquez Villalba C. Genomic analysis of the first isolate of KPC-2-producing Klebsiella pneumoniae from Uruguay. J Glob Antimicrob Resist. 2018 Dec;15:109-110. doi: 10.1016/j.jgar.2018.09.001.

- Montaña S, Hernandez M, Fernandez JS, Pennini M, Centrón D, Sucari A, Iriarte A, Ramírez MS. Molecular characterization of KPC-2-positive Klebsiella pneumoniae isolates from a neurosurgical centre in Argentina. New Microbes New Infect. 2018 Apr 21;24:32-34. doi: 10.1016/j.nmni.2018.04.002.

- Rodríguez C, Brengi S, Cáceres MA, Mochi S, Viñas MR, Rizza CA, Merletti G, Bru E, Assa JD, Raya RR, Centrón D. Successful management with fosfomycin + ceftazidime of an infection caused by multiple highly-related subtypes of multidrug-resistant and extensively drug-resistant KPC-producing Serratia marcescens. Int J Antimicrob Agents. 2018 Nov;52(5):737-739. doi:10.1016/j.ijantimicag.2018.07.020.

- Alonso CA, Cortés-Cortés G, Maamar E, Massó M, Rocha-Gracia RDC, Torres C, Centrón D, Quiroga MP. Molecular diversity and conjugal transferability of class 2 integrons among Escherichia coli isolates from food, animal and human sources. Int J Antimicrob Agents. 2018 Jun;51(6):905-911. doi:10.1016/j.ijantimicag.2018.02.001. Epub 2018 Feb 8. Erratum in: Int J Antimicrob Agents. 2019 Dec;54(6):834.

- Martini MC, Quiroga MP, Pistorio M, Lagares A, Centrón D, Del Papa MF. Novel environmental class 1 integrons and cassette arrays recovered from an on-farm bio-purification plant. FEMS Microbiol Ecol. 2018 Mar 1;94(3). doi: 10.1093/femsec/fix190.

- Chamosa LS, Álvarez VE, Nardelli M, Quiroga MP, Cassini MH, Centrón D. Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment. Sci Rep. 2017 Mar 31;7(1):513. doi: 10.1038/s41598-017-00600-2.

- Rodríguez C, Brengi S, Cáceres MA, Mochi S, Viñas MR, Merletti G, Raya RR, Centrón D. Polyclonal dissemination of KPC-2 in Serratia marcescens, including a clone with epidemic behaviour in the nosocomial niche. Int J Antimicrob Agents. 2017 May;49(5):657-658. doi: 10.1016/j.ijantimicag.2017.03.003.

- Rodríguez C, Cassini MH, del V. Delgado G, Argentinian Integron Study Group, Ramírez MS, Centrón D. Analysis of class 2 integrons as a marker for multidrug resistance among Gram negative bacilli[J]. AIMS Genetics, 2016, 3(4): 196-204. doi: 10.3934/genet.2016.4.196

- Parmeciano Di Noto G, Jara E, Iriarte A, Centrón D, Quiroga C. Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element carrying an integron platform inserted in a novel genomic locus. Microbiology (Reading). 2016 Aug;162(8):1335-1345. doi: 10.1099/mic.0.000310.

- Quiroga MP, Orman B, Errecalde L, Kaufman S, Centrón D. Characterization of Tn6238 with a new allele of aac(6')-Ib-cr. Antimicrob Agents Chemother. 2015 May;59(5):2893-7. doi: 10.1128/AAC.03213-14.

- Ramírez MS, Montaña S, Cassini M, Centrón D. Preferential carriage of class 2 integrons in Acinetobacter baumannii CC113 and novel singletons. Epidemiol Infect. 2015 Oct;143(14):3118-21. doi: 10.1017/S0950268815000060.

- Vilacoba E, Quiroga C, Pistorio M, Famiglietti A, Rodríguez H, Kovensky J, Déraspe M, Raymond F, Roy PH, Centrón D. A blaVIM-2 plasmid disseminating in extensively drug-resistant clinical Pseudomonas aeruginosa and Serratia marcescens isolates. Antimicrob Agents Chemother. 2014 Nov;58(11):7017-8. doi: 10.1128/AAC.02934-14.