Laboratorio de Modelos Experimentales de enfermedad de Chagas (LaMECh)
Director:
Dr. Mirkin, Gerardo A. I.
Integrantes:
Lic. Rada, María Jimena
Colaboradores del Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, INBIRS UBA-CONICET:
Dra. Goren, Nora B.
Dr. Penas, Federico N.
Dra. Cevey, Ágata C.
El LaMECh desarrolla modelos animales de la enfermedad de Chagas, que permiten estudiar los mecanismos inflamatorios de la cardiomiopatía chagásica crónica.
El objetivo central es identificar alternativas terapéuticas que permitan, junto con el tratamiento etiológico específico, limitar la respuesta inflamatoria exacerbada que lleva al progresivo deterioro de la función cardíaca en esta patología.
Publicaciones destacadas:
- Rada J, Donato M, Penas FN, Alba Soto C, Cevey ÁC, Pieralisi AV, Gelpi R, Mirkin GA, Goren NB. IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease. Front Immunol. 2020 Sep 24;11:572178. doi: 10.3389/fimmu.2020.572178.
- Penas FN, Carta D, Cevey ÁC, Rada MJ, Pieralisi AV, Ferlin MG, Sales ME, Mirkin GA, Goren NB. Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway in T. cruzi-Infected Macrophages. Front Immunol. 2020 Jan 9;10:2955. doi: 10.3389/fimmu.2019.02955.
- Cevey ÁC, Mirkin GA, Donato M, Rada MJ, Penas FN, Gelpi RJ, Goren NB. Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease. Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):378-387. doi: 10.1016/j.ijpddr.2017.10.003.
- Cevey ÁC, Mirkin GA, Penas FN, Goren NB. Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain. Int J Parasitol Drugs Drug Resist. 2015 Dec 12;6(1):12-22. doi: 10.1016/j.ijpddr.2015.12.001.
- Penas F, Mirkin GA, Hovsepian E, Cevey A, Caccuri R, Sales ME, Goren NB. PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi. Biochim Biophys Acta. 2013 Jan;1832(1):239-48. doi: 10.1016/j.bbadis.2012.08.007.