Laboratorio de Investigaciones de Mecanismos de Resistencia a Antibióticos

 

Directoras:

Dra. Centrón, Daniela

Dra. Quiroga, Maria Paula

 

Integrantes:

Dra. Alvarez, Verónica Elizabeth
Lic. Alonso, Fernando Martín
Lic. Ayala Nuñez, Teolincacihuatl
Lic. Carrera Paez, Laura Camila
Lic. Galán Delgado, Angélica Viviana
Lic. Gambino, Anahí Samanta
Lic. Massó, Mariana Guillermina
Lic. Vianna, Lorena


Actualmente estamos trabajando en identificar los procesos celulares y moleculares que llevan a la diseminación de los genes de resistencia a antibióticos del ambiente a la clínica en ambas direcciones.


Publicaciones destacadas:

1- Successful management with fosfomycin/ceftazidime of an infection caused by multiple highly related subtypes of MDR and XDR KPC-producing Serratia marcescens. Int J Antimicrob Agents. Aug 6. pii: S0924-8579(18)30219-X. doi: 10.1016/j.ijantimicag. 2018. Rodríguez C, Brengi S, Cáceres MA, Mochi S, Viñas MR, Rizza CA, Merletti G, Bru E, Assa JD, Raya RR, Centrón D.
2- Molecular diversity and conjugal transferability of class 2 integrons among escherichia coli isolates from food, animal and human sources. Int J Antimicrob Agents. Feb 8. pii: S0924-8579(18)30039-6. doi: 10.1016. 2018. Alonso CA, Cortés-Cortés G, Maamar E, Massó M, Rocha-Gracia RDC, Torres C, Centrón D, Quiroga MP.
3- Novel environmental class 1 integrons and cassette arrays recovered from an on-farm bio-purification plant. FEMS Microbiol Ecol. Mar 1;94(3). doi: 10.1093. 2018. Martini MC, Quiroga MP, Pistorio M, Lagares A, Centrón D, Del Papa MF.
4- Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment. Scientific Reports. Mar 31;7(1):513. doi: 10.1038/s41598-017-00600-2. 2017. Chamosa L, Álvarez VE, Nardelli M, Quiroga MP, Cassini M, Centrón D.
5- Polyclonal dissemination of KPC-2 in Serratia marcescens, including a clone with epidemic behaviour in the nosocomial niche. Int J Antimicrob Agents. Mar 20. pii: S0924-8579(17)30087-0. doi: 10.1016/j.ijantimicag.2017.03.003. 2017. Rodríguez C, Brengi S, Cáceres MA, Mochi S, Viñas MR, Merletti G, Raya RR, Centrón D.
6- Analysis of class 2 integrons as a marker for multidrug resistance among Gram negative bacilli. AIMS Genetics. 2016. Rodríguez C, Cassini MH, Delgado G, Argentinian Integron Study Group, Ramírez MS, Centrón D.
7- Genome analysis of a clinical isolate of Shewanella sp. uncovered an active hybrid integrative and conjugative element (ICE) carrying an integron platform inserted in a novel genomic locus. Microbiology. May 23. doi: 10.1099/mic.0.000310. 2016. Parmeciano Di Noto G, Jara E, Iriarte A, Centrón D, Quiroga C. IF:2,268.
8- Characterization of Tn6238 with a new variant of aac(6’)-Ib-cr. Antimicrob. Agents Chemother. 59(5):2893-7. doi: 10.1128/AAC.03213-14. 2015. Quiroga MP, Orman, BE, Errecalde L, Kaufman S, Centrón D.
9- Preferential carriage of class 2 integrons in Acinetobacter baumannii CC113 and novel singletons. Epidemiol. Infect. 20:1-4. 2015. Ramírez MS, Montaña S, Cassini M, Centrón D.
10- A blaVIM-2 plasmid disseminating in extensively drug-resistant clinical Pseudomonas aeruginosa and Serratia marcescens isolates. Antimicrob. Agents Chemother. Nov;58(11):7017-8. doi: 10.1128/AAC.02934-14. 2014. Vilacoba E, Quiroga C, Pistorio M, Famiglietti A, Rodríguez H, Kovensky J, Déraspe M, Raymond F, Roy PH, Centrón