Laboratorio de Genómica y Bioinformática de Patógenos

 

Directora:

Dra. Kamenetzky, Laura

 

Integrantes:

Dr. Lichtenstein, Gabriel

Dr. Maldonado, Lucas Luciano

Dra. Macchiaroli, Natalia

Lic. Ancarola, Eugenia


Obtenemos, analizamos e integramos datos x-ómicos de patógenos de interés en salud humana y animal mediante herramientas bioinformáticas y de biología molecular.


Publicaciones destacadas:

1: Basika T, Paludo GP, Araujo FM, Salim AC, Pais F, Maldonado L, Macchiaroli N, Camargo de Lima J, Rosenzvit M, Oliveira GC, Kamenetzky L, Ferreira HB. Transcriptomic profile of two developmental stages of the cestode parasite Mesocestoides corti. Mol Biochem Parasitol. 2019 Apr;229:35-46. doi: 10.1016/j.molbiopara.2019.02.006. Epub 2019 Feb 21. PubMed PMID: 30797776.

2: Maldonado LL, Stegmayer G, Milone DH, Oliveira G, Rosenzvit M, Kamenetzky L. Whole genome analysis of codon usage in Echinococcus. Mol Biochem Parasitol. 2018 Oct;225:54-66. doi: 10.1016/j.molbiopara.2018.08.001. Epub 2018 Aug 3. PubMed PMID: 30081061.

3: International Molecular Helminthology Annotation Network (IMHAN); IMHAN consortium authors include, Palevich N, Britton C, Kamenetzky L, Mitreva M, de Moraes Mourão M, Bennuru S, Quack T, Scholte LLS, Tyagi R, Slatko BE. Tackling Hypotheticals in Helminth Genomes. Trends Parasitol. 2018 Mar;34(3):179-183. doi: 10.1016/j.pt.2017.11.007. Epub 2017 Dec 14. PubMed PMID: 29249363.

4: Stegmayer G, Yones C, Kamenetzky L, Macchiaroli N, Milone DH. Computational Prediction of Novel miRNAs from Genome-Wide Data. Methods Mol Biol. 2017;1654:29-37. doi: 10.1007/978-1-4939-7231-9_3. PubMed PMID: 28986781.

5: Carnevale S, Malandrini JB, Pantano ML, Soria CC, Rodrigues-Silva R, Machado-Silva JR, Velásquez JN, Kamenetzky L. First genetic characterization of Fasciola hepatica in Argentina by nuclear and mitochondrial gene markers. Vet Parasitol. 2017 Oct 15;245:34-38. doi: 10.1016/j.vetpar.2017.08.006. Epub 2017 Aug 12. PubMed PMID: 28969834.

6: Arrabal JP, Avila HG, Rivero MR, Camicia F, Salas MM, Costa SA, Nocera CG, Rosenzvit MC, Kamenetzky L. Echinococcus oligarthrus in the subtropical region of Argentina: First integration of morphological and molecular analyses determines two distinct populations. Vet Parasitol. 2017 Jun 15;240:60-67. doi: 10.1016/j.vetpar.2017.03.019. Epub 2017 Mar 27. PubMed PMID: 28433410.

7: Maldonado LL, Assis J, Araújo FM, Salim AC, Macchiaroli N, Cucher M, Camicia F, Fox A, Rosenzvit M, Oliveira G, Kamenetzky L. The Echinococcus canadensis (G7) genome: a key knowledge of parasitic platyhelminth human diseases. BMC Genomics. 2017 Feb 27;18(1):204. doi: 10.1186/s12864-017-3574-0. PubMed PMID: 28241794; PubMed Central PMCID: PMC5327563.

8: Avila HG, Santos GB, Cucher MA, Macchiaroli N, Pérez MG, Baldi G, Jensen O, Pérez V, López R, Negro P, Scialfa E, Zaha A, Ferreira HB, Rosenzvit M, Kamenetzky L. Implementation of new tools in molecular epidemiology studies of Echinococcus granulosus sensu lato in South America. Parasitol Int. 2017 Jun;66(3):250-257. doi: 10.1016/j.parint.2017.02.001. Epub 2017 Feb 11. PubMed PMID: 28193534.

9: Kamenetzky L, Stegmayer G, Maldonado L, Macchiaroli N, Yones C, Milone DH. MicroRNA discovery in the human parasite Echinococcus multilocularis from genome-wide data. Genomics. 2016 Jun;107(6):274-80. doi:
10.1016/j.ygeno.2016.04.002. Epub 2016 Apr 21. PubMed PMID: 27107656.

10: Cucher MA, Macchiaroli N, Baldi G, Camicia F, Prada L, Maldonado L, Avila HG, Fox A, Gutiérrez A, Negro P, López R, Jensen O, Rosenzvit M, Kamenetzky L. Cystic echinococcosis in South America: systematic review of species and genotypes of Echinococcus granulosus sensu lato in humans and natural domestic hosts. Trop Med Int Health. 2016 Feb;21(2):166-75. doi: 10.1111/tmi.12647. Epub 2015 Dec 28. Review. PubMed PMID: 26610060